Adjuvant radiation treatment after prostatectomy. Where do we stand?
نویسندگان
چکیده
INTRODUCTION Prostate cancer is the second most common cause of cancer death in American men. For patients with adverse pathologic features, postoperative radiotherapy to prostate bed after radical prostatectomy has been shown in randomized studies to improve many important clinical endpoints including overall survival. In this review article, we distinguish adjuvant radiation treatment (ART) from salvage radiation treatment (SRT), discuss the evidences for ART and its potential side effects focusing on the debate concerning the optimal timing of post prostatectomy radiation treatment (RT). MATERIAL AND METHODS A comprehensive literature search was conducted in MEDLINE including pre-MEDLINE. CONCLUSION for patients with adverse pathologic factors, adjuvant radiation treatment after prostatectomy reduces the rate of PSA failure with the potential for significantly improving metastases-free and overall survival. Whether an equivalent survival benefit can be attained with early salvage radiation treatment after biochemical recurrence, is still an area of debate.
منابع مشابه
Radiation Therapy after Radical Prostatectomy for Prostate Cancer: Evaluation of Complications and Influence of Radiation Timing on Outcomes in a Large, Population-Based Cohort
PURPOSE To evaluate the influence of timing of salvage and adjuvant radiation therapy on outcomes after prostatectomy for prostate cancer. METHODS Using the Surveillance, Epidemiology, and End Results-Medicare linked database, we identified prostate cancer patients diagnosed during 1995-2007 who had one or more adverse pathological features after prostatectomy. The final cohort of 6,137 eligi...
متن کاملRadiation therapy after radical prostatectomy for prostate cancer: evaluation of complications and influence of radiation timin
To evaluate the influence of timing of salvage and adjuvant radiation therapy on outcomes after prostatectomy for prostate cancer. Using the Surveillance, Epidemiology, and End Results-Medicare linked database, we identified prostate cancer patients diagnosed during 1995-2007 who had one or more adverse pathological features after prostatectomy. The final cohort of 6,137 eligible patients inclu...
متن کاملOutcomes for radiation therapy after radical prostatectomy for prostate cancer: what really matters?
This comment should start with the acknowledgement that we are firm advocates of the value of radiotherapy (RT) after radical prostatectomy (RP) in many patients with prostate cancer. However, we are concerned that a published and recently presented study (European Organization for Research and Treatment of Cancer, EORTC, Trial 22911) by Bolla et al. [1,2], of adjuvant RT vs observation for pat...
متن کاملQuality of Radiation Therapy Referral and Utilisation Post-prostatectomy: A Population-based Study of Time Trends.
AIMS Adjuvant radiotherapy post-prostatectomy has been shown to benefit patients with adverse pathology. It remains unclear whether salvage radiotherapy confers equivalent outcomes. Practice guidelines recommend referral to radiation oncology within 6 months after prostatectomy to discuss adjuvant and salvage radiotherapy. The study objectives were to assess, at a population level: (i) post-pro...
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ورودعنوان ژورنال:
- The Canadian journal of urology
دوره 18 2 شماره
صفحات -
تاریخ انتشار 2011